In the sixth episode of The Deep End, we follow up on Jon and his family’s journey with DBS treatment for depression and explore the ongoing research in the field. A clinical trial of DBS for treatment-resistant depression has just begun, with the first volunteer undergoing surgery in early February. We also witness the evolving meaning of a beloved song for Jon and Barbara in their post-DBS lives.
The Nelson family, especially Jon, has found relief and moments of joy after DBS surgery. Despite his continued irritability, Jon and his family are able to look back and joke about the challenges they faced during his depression. The family dynamic has shifted to a place of lightness, laughter, and kindness, with a focus on enjoying the present moment and being grateful for every day.
Barbara opens up about the importance of sharing their story to help others going through similar struggles. Patient 001 and Amanda also express the significance of shedding light on their experiences to offer hope and guidance to those in the dark. The impact of DBS treatment goes beyond individual recovery to inspire others to seek help and find their own way out of depression.
The podcast delves into the current state of DBS research, the challenges scientists face in understanding its effectiveness, and the potential for future advancements. A new clinical trial funded by Abbott aims to study DBS in a larger sample of individuals with treatment-resistant depression to clarify its mechanisms and outcomes. Researchers are also exploring alternative non-invasive treatments that may provide relief without the need for brain surgery.
Helen Mayberg, a key figure in DBS research, emphasizes the collaborative effort with patients like Jon, Amanda, and Emily to advance the understanding of depression and its treatment. While the science is still evolving, the progress made in identifying brain markers and behavioral changes in response to DBS offers hope for future innovations in mental health care.
As the research continues, the focus shifts towards finding simpler, more accessible treatments for depression that can benefit a wider population. The ultimate goal is to create effective therapies that can improve the lives of many individuals struggling with mental health issues. The stories of Jon, Barbara, Amanda, and others serve as a source of inspiration and motivation for researchers and patients alike to continue the fight against depression.
